Journal
ORGANIC LETTERS
Volume 5, Issue 23, Pages 4473-4475Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol035781y
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Silver iodide catalyzed the three-component coupling of aldehyde, alkyne, and amines to generate propargylic amines with high efficiency in water. The silver-catalyzed reaction is especially effective for reactions involving aliphatic aldehyde. No additional cocatalyst or activator is required.
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