Journal
ORGANIC LETTERS
Volume 5, Issue 23, Pages 4257-4259Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol035333q
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The Friedlander synthesis of quinolines is an extensively employed protocol, yielding the desired heterocycle in a two-step reduction-condensation sequence. We have developed a mild, efficient, high-yielding single-step variant of this methodology, which employs SnCl2 and ZnCl2 to effect the reaction.
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