Journal
ORGANIC LETTERS
Volume 5, Issue 23, Pages 4369-4372Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol035651p
Keywords
-
Categories
Funding
- NCI NIH HHS [CA27489] Funding Source: Medline
Ask authors/readers for more resources
Direct catalytic aldol reactions of alpha,alpha-dialkylaldehyde donors and arylaldehyde acceptors have been performed using pyrrolidine-acetic acid bifunctional catalysts. This general and practical amine-acid combination was identified by screening catalysts using a new fluorescent detection system for carbon-carbon bond formation. Using 0.05 equiv of pyrrolidine and 0.25 equiv of acetic acid as catalyst, we obtained alpha,alpha-dialkylaldol product in 96% yield after 2 h at ambient temperature. Proline was a poor catalyst of this reaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available