Journal
ORGANIC LETTERS
Volume 5, Issue 23, Pages 4465-4468Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol035778e
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3,4,5-Trisubstituted 1,2,4-triazoles were synthesized in solution from various thioamides and hydrazides in smooth experimental conditions leading to peptidomimetic scaffolds. This strategy was found to be compatible with the usual peptide synthesis protecting groups. This methodology was then applied on solid support by anchoring alpha-amino acids through their amino function to an activated carbonate resin.
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