Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 23, Pages 9116-9118Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo035140g
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The most potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.
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