Journal
BRAIN RESEARCH
Volume 990, Issue 1-2, Pages 221-226Publisher
ELSEVIER
DOI: 10.1016/S0006-8993(03)03528-5
Keywords
epilepsy; Cl- channel; Cl- cotransporter; GABA; KCC; NKCC
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In a rat kindling model, we examined expression patterns of NKCC1, KCC1, KCC2, and CLC-2. In the dentate granule cell layer, there was an activity-dependent increase in NKCC1 mRNA but significant decreases in KCC1 and CLC-2 mRNAs. In addition, CLC-2 mRNA expression was markedly decreased in CA1 pyramidal layer. These results suggest that an increase in [Cl-](i) and a resultant reduction in GABAergic inhibition may occur in hippocampus of epileptic rats. (C) 2003 Elsevier B.V. All rights reserved.
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