Journal
TETRAHEDRON-ASYMMETRY
Volume 14, Issue 22, Pages 3589-3592Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2003.09.018
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The hydrolytic kinetic resolution of racemic terminal epoxides utilizing chiral (salen)Co(III) catalysts provides practical access to enantiopure epoxides and diols. However, general issues surrounding catalyst activation combined with the specific problem of racemization of epichlorohydrin served to make the large-scale production of (R)- or (S)-epichlorohydrin difficult and uneconomical. A process for the large-scale production and isolation of active (salen)Co(III)OAc catalyst and a method of catalyst reduction after reaction using ascorbic acid have been developed to overcome these issues. (C) 2003 Elsevier Ltd. All rights reserved.
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