Journal
ARCHIVES OF GERONTOLOGY AND GERIATRICS
Volume 58, Issue 1, Pages 153-159Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.archger.2013.07.007
Keywords
Lutein; Lifespan; Drosophila melanogaster; Malonyldialdehyde; Superoxide dismutase; Catalase
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Funding
- National Science-technology pillar program [2011BAD23B02, 2012BAD33B05]
- National Natural Science Foundation of China [31201322]
- Higher education science & technology development project of Tianjin [20100609]
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Lutein is one of the major carotenoids in most fruits and vegetables. The effect of lutein on the lifespan of Drosophila melanogaster was investigated. Results revealed that 0.1 mg lutein/ml diet could prolong their mean lifespan from 49.0 to 54.6 days. This was consistent with a significant reduction in malonyldialdehyde (MDA) level and increase in antioxidant enzyme activities of the flies fed with lutein-treated diet compared with those fed with basal diet. Paraquat (PQ) and H2O2 treatment tests demonstrated that lutein could prolong the survival time of the flies. Real-time polymerase chain reaction (RT-PCR) analysis indicated the gene expression of superoxide dismutase (SOD; SOD1 and SOD2), and catalase (CAT) in the lutein-treated group was up-regulated relative to that of the control group. It was concluded that the lifespan-prolonging activity of lutein was partially by up-regulation of endogenous antioxidant enzymes. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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