Journal
JOURNAL OF CELL SCIENCE
Volume 116, Issue 22, Pages 4493-4499Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00829
Keywords
Bcl-2; endoplasmic reticulum; ER; mitochondria; Bcl-Cb5; calcium; BH3-only; cytochrome c
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Funding
- NCI NIH HHS [R01 CA85804, T32 CA73515] Funding Source: Medline
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Bcl-2 has been described both as an inhibitor of programmed cell death and as an inhibitor of mitochondrial dysfunction during apoptosis. It is still not clear what biochemical activity of Bcl-2 is responsible for its function, but increasing evidence indicates that a functional activity of Bcl-2 on the endoplasmic reticulum (ER) protects mitochondria under diverse circumstances. Indeed, an emerging hypothesis is that, during apoptosis, the Bcl-2 family regulates ER-to-mitochondrion communication by BH3-only proteins and calcium ions and thereby triggers mitochondrial dysfunction and cell death.
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