Journal
TETRAHEDRON LETTERS
Volume 44, Issue 47, Pages 8585-8588Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2003.09.155
Keywords
peptide synthesis; photolabile protecting group; photolithography; microarray
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The 2-(2-nitrophenyl)propyloxycarbonyl (NPPOC) group has been introduced as a photolabile amino protecting group for amino acids to be used as building blocks in photolithographic solid-phase peptide synthesis. NPPOC-protected amino acids were found to be cleaved in the presence of UV light about twice as fast as the corresponding o-nitroveratryloxycarbonyl (NVOC)-protected amino acids. (C) 2003 Elsevier Ltd. All rights reserved.
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