Journal
NEUROSCIENCE LETTERS
Volume 351, Issue 3, Pages 177-180Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.08.009
Keywords
N-methyl-D-aspartate receptor; non-N-methyl-D-aspartate receptor; dizocilpine; 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline; arthritis; pain
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To determine whether both the N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the knee joint contribute to the induction and/or maintenance of arthritic pain, we examined the effects of intra-articular injection of NNIDA receptor antagonist dizocilpine (MK-801) and non-NMDA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline (NBQX) on the decrease in weight load induced by carrageenan injection into the knee joint cavity in rats. Injection of MK-801 (0.75 and 1.5 mM) and NBQX (0.25, 0.625 and 2.5 mM) immediately prior to carrageenan injection (2%, 40 mul) significantly prevented the pain-related behavior. However, injection of MK-801 (0.75 and 1.5 mM) and NBQX (0.625 and 2.5 mM) 5 h after carrageenan injection had no effect on pain-related behavior. These results suggest that both the NMDA and non-NMDA receptors in the knee joint are involved in the induction, but not maintenance, of arthritic pain. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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