Journal
FEBS LETTERS
Volume 554, Issue 3, Pages 247-252Publisher
WILEY
DOI: 10.1016/S0014-5793(03)00975-X
Keywords
malaria; Raman spectroscopy; hemozoin; beta-hematin; Plasmodium falciparum
Funding
- NIDDK NIH HHS [DK32094-10] Funding Source: Medline
- PHS HHS [A144008-04A1] Funding Source: Medline
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Micro-Raman spectra of hemozoin encapsulated within the food vacuole of a Plasmodium falciparum-infected erythrocyte are presented. The spectrum of hemozoin is identical to the spectrum of beta-hematin at all applied excitation wavelengths. The unexpected observation of dramatic band enhancement of A(1g) modes including nu(4) (1374 cm(-1)) observed when applying 780 nm excitation enabled Raman imaging of hemozoin in the food vacuole. This unusual enhancement, resulting from excitonic coupling between linked porphyrin moieties in the extended porphyrin array, enables the investigation of hemozoin within its natural environment for the first time. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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