Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 225, Issue 2, Pages 147-151Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S0022-5193(03)00221-2
Keywords
tumor growth kinetics; tumor therapy; methametical modelling; universal law; metastasis; angiogenesis; invasion
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A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a universal law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion. (C) 2003 Published by Elsevier Ltd.
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