Journal
SCIENCE
Volume 302, Issue 5649, Pages 1396-1398Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1090284
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Funding
- NIAID NIH HHS [R01 AI033077, AI33077, R01 AI033077-10] Funding Source: Medline
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Herpes simplex virus, a DNA virus of high complexity, consists of a nucleocapsid surrounded by the tegument-a protein compartment-and the envelope. The latter components, essential for infectivity, are pleiomorphic. Visualized in cryo-electron tomograms of isolated virions, the tegument was seen to form an asymmetric cap: On one side, the capsid closely approached the envelope; on the other side, they were separated by similar to35 nanometers of tegument. The tegument substructure was particulate, with some short actin-like. laments. The envelope contained 600 to 750 glycoprotein spikes that varied in length, spacing, and in the angles at which they emerge from the membrane. Their distribution was nonrandom, suggesting functional clustering.
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