Journal
LANCET
Volume 362, Issue 9397, Pages 1723-1724Publisher
LANCET LTD
DOI: 10.1016/S0140-6736(03)14847-7
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Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type I diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type I diabetes than is G241 (3695 families, relative risk 0.91, p=0-03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type I diabetes, which needs to be confirmed In future genetic and functional experiments.
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