4.4 Article

Palladium catalyzed reaction in aqueous DMF: synthesis of 3-alkynyl substituted flavones in the presence of prolinol

Journal

TETRAHEDRON
Volume 59, Issue 48, Pages 9563-9570

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2003.10.003

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(S)-Prolinol facilitated the coupling reaction of terminal alkynes with 3-iodoflavone under palladium-copper catalysis in aqueous DMF affording a mild and convenient method for the synthesis of 3-alkynyl substituted flavones of potential biological interest. (C) 2003 Elsevier Ltd. All rights reserved.

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