Journal
NEUROSCIENCE LETTERS
Volume 352, Issue 1, Pages 67-69Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.08.011
Keywords
Alzheimer's disease; mild cognitive impairment; cerebrospinal fluid; biochemical markers; beta-amyloid; total-tau; phospho-tau
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A major diagnostic challenge when people seek advice for cognitive dysfunction is to differentiate between mild cognitive impairment (MCI) and incipient Alzheimer's disease (AD). We show that a combination of three cerebrospinal fluid biochemical markers, total-tau, phospho-tau and beta-amyloid(1-42), can detect incipient AD among patients fulfilling the criteria for MCI with a sensitivity of 68% (95% CI 45-86%) and a specificity of 97% (95% CI 83-100%). The usefulness of these markers is further emphasized by the finding of a positive predictive value of 94% and a negative predictive value of 81%. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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