Journal
ARCHIVES OF GENERAL PSYCHIATRY
Volume 69, Issue 7, Pages 750-753Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/archgenpsychiatry.2011.2280
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Funding
- National Institutes of Health [R01 MH078160, R01 MH085328, P41 RR15241]
- Johns Hopkins University School of Medicine Institute for Clinical and Translational Research National Institutes of Health/National Center for Research Resources [UL1 RR025005]
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Context: Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterized by a deficit in behavioral inhibition. Recent evidence also suggests a deficit in cortical inhibition via the GABA (gamma-aminobutyric acid)-ergic system. Objective: To investigate the GABAergic component of ADHD using magnetic resonance spectroscopy. Design: Cross-sectional study. Setting: Participants were recruited through local schools, local pediatric and other community clinics, and through advertisement in regional publications. Magnetic resonance spectroscopy was performed within the research institute. Participants: Children (age range, 8-12 years) in a typically developing control group vs a group with ADHD were compared. Main Outcome Measures: J-difference-edited magnetic resonance spectroscopy at 3 T was used to measure GABA concentration in a volume that included primary somatosensory and motor cortices. Results: GABA concentration is reduced in children with ADHD compared with typically developing control subjects. Conclusion: Our finding of reduced GABA concentration in ADHD is concordant with recently reported deficits in short intracortical inhibition in ADHD and suggests a GABAergic deficit in ADHD.
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