New oxazole-based peptidomimetics: Useful building blocks for the synthesis of orthogonally protected macrocyclic scaffolds

The synthesis of a new family of densely functionalized oxazole-containing amino acids is described. These building blocks were employed for preparing macrocycles containing Lys and Glu residues by a combination of solid- and solution-phase synthesis. The resulting structures are presented as orthogonally protected scaffolds for supramolecular chemistry.