Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 532, Issue 1-2, Pages 41-58Publisher
ELSEVIER
DOI: 10.1016/j.mrfmmm.2003.08.009
Keywords
checkpoints; DNA damage; DNA repair; DNA replication
Funding
- Telethon [E.1247] Funding Source: Medline
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Cells are never more vulnerable than during DNA replication, which represents a major moment of potential genetic instability. Genotoxic insults induce many different forms of DNA damage that may interfere with the ability of cells to properly duplicate their genome. Primary damage may in turn undergo structural transformations during DNA replication, thus generating secondary lesions that may be even more dangerous. Cells experiencing replication of damaged DNA or replication blocks activate an S-phase checkpoint response that assures the fidelity and completion of DNA replication before cells enter M-phase. The S-phase checkpoint pathway regulates not only progress through the cell cycle but also DNA repair and DNA replication itself. (C) 2003 Elsevier B.V. All rights reserved.
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