Journal
FEBS LETTERS
Volume 555, Issue 1, Pages 57-61Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)01103-7
Keywords
phagocyte; respiratory burst; ion channel; membrane potential; superoxide; pH
Funding
- NHLBI NIH HHS [R01 HL061437, HL61437, HL52671] Funding Source: Medline
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Leukocytes kill microbes by producing reactive oxygen species, using a multi-component enzyme complex, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Electrons pass from intracellular NADPH through a redox chain within the enzyme, to reduce extracellular O-2 to O-2(-). Electron flux is electrogenic, and rapidly depolarizes the membrane potential. Excessive depolarization can turn off electron transport by self-inhibition, but this is prevented by proton flux that balances the electron flux. Although the membrane potential depolarizes by similar to 100 mV during the respiratory burst (NADPH oxidase activity), NADPH oxidase activity is independent of voltage in this range, which permits optimal function and prevents self-inhibition. (C) 2003 Federation of European Biochemical Societies. Published by Else-tier B.V. All rights reserved.
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