Journal
CIRCULATION RESEARCH
Volume 93, Issue 11, Pages 1029-1033Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000102869.39150.23
Keywords
antioxidants; cardiovascular diseases; endothelium; smooth muscle; signal transduction
Funding
- NHLBI NIH HHS [HL-64839, HL-62826] Funding Source: Medline
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The thioredoxin (TRX) system (TRX, TRX reductase, and NADPH) is a ubiquitous thiol oxidoreductase system that regulates cellular reduction/ oxidation ( redox) status. The oxidation mechanism for disease pathogenesis states that an imbalance in cell redox state alters function of multiple cell pathways. In this study, we review the essential role for TRX to limit oxidative stress directly via antioxidant effects and indirectly by protein-protein interaction with key signaling molecules, such as apoptosis signal-regulating kinase 1. We propose that TRX and its endogenous regulators are important future targets to develop clinical therapies for cardiovascular disorders associated with oxidative stress.
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