Journal
SCIENCE
Volume 302, Issue 5650, Pages 1569-1571Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1090956
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- NIAID NIH HHS [N01-AI-95359] Funding Source: Medline
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Vancomycin is usually reserved for treatment of serious infections, including those caused by multidrug-resistant Staphylococcus aureus. A clinical isolate of S. aureus with high-level resistance to vancomycin ( minimal inhibitory concentration = 1024 mug/ml) was isolated in June 2002. This isolate harbored a 57.9-kilobase multiresistance conjugative plasmid within which Tn1546 (vanA) was integrated. Additional elements on the plasmid encoded resistance to trimethoprim (dfrA), beta-lactams (blaZ), aminoglycosides (aacA-aphD), and disinfectants ( qacC). Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn1546 from a co-isolate of Enterococcus faecalis.
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