Journal
ARCHIVES OF GENERAL PSYCHIATRY
Volume 68, Issue 8, Pages 853-861Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/archgenpsychiatry.2011.72
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Categories
Funding
- Abbott
- AstraZeneca
- Avid
- Baxter
- Elan Pharmaceuticals
- GlaxoSmithKline
- Johnson Johnson
- Eli Lilly
- Medivation
- Merck
- Myriad
- Pfizer
- Takeda
- Wyeth
- AC Immune
- Acadia
- Adamas
- Allergan
- Bristol-Myers Squibb
- Eisai
- Elan
- Epix
- Forest
- Medavante
- Roche
- sanofi-aventis
- Schering-Plough
- Toyama
- Transition Therapeutics
- Worldwide Clinical Trials
- Alzheimer's Association
- Forest Laboratories
- Novartis
- Abbott Laboratories
- Accera
- Allon
- Alzheimer Drug Discovery Foundation
- Exonhit
- Institute IPSEN
- Lundbeck
- Servier
- Schwabe
- Teva
- Voyager
- National Institute on Aging (NIA) [U01 AG 10483]
- National Institute of Mental Health
- BMS
- Janssen
- Mitsubishi
- Myriad Neurosciences
- Neurochem
- Ono Pharma
- Sanofi
- NIH [NIA U01-AG10483, NIA U01-AG024904, NIA R01-AG030048, R01-AG16381]
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Context: Agitation and psychosis are common in Alzheimer disease and cause considerable morbidity. We attempted to delay or to prevent agitation and psychosis with the use of divalproex sodium (valproate). Objective: To determine whether treatment with valproate could delay or prevent emergence of agitation or psychosis. Design, Setting, and Patients: A multicenter, randomized, double-blind, placebo-controlled trial of flexible-dose valproate in 313 (of 513 screened) individuals with moderate Alzheimer disease who had not yet experienced agitation or psychosis. The study was conducted from November 1, 2005, through March 31, 2009, at 46 sites in the United States. Intervention: Participants were randomly assigned to valproate treatment at a target dose of 10 to 12 mg per kilogram of body weight per day or identical-appearing placebo for 24 months followed by a 2-month period of single-blind placebo treatment. Main Outcome Measure: Time to emergence of clinically significant agitation or psychosis. Results: A total of 122 participants (59 receiving valproate and 63 receiving placebo) completed 24 months of treatment while taking study medication; 42 (27 receiving valproate and 15 receiving placebo) reached 24 months having discontinued study medication; 150 reached month 26. There was no difference between groups in time to emergence of agitation or psychosis (Cox proportional hazard ratio, 0.96; P=.88). There was no difference between groups in change on any secondary outcome. The valproate group had higher rates of somnolence, gait disturbance, tremor, diarrhea, and weakness. Eighty-eight participants underwent magnetic resonance imaging scans at baseline and 12 months; the valproate group showed greater loss in hippocampal and whole-brain volume, accompanied by greater ventricular expansion (P <.001). Conclusion: Valproate treatment did not delay emergence of agitation or psychosis or slow cognitive or functional decline in patients with moderate Alzheimer disease and was associated with significant toxic effects.
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