Screening of plant extracts for antiprotozoal and cytotoxic activities

Methanolic and aqueous extracts derived from 43 plant species, selected either from ethnobotanical or chemotaxonomical data, were screened for their antiprotozoal activity against Leishmania donovani and Trypanosoma brucei brucei. The cytotoxic activity against KB cells was also determined. Eight extracts had IC50 values of less than 10 mug/ml against Leishmania donovani. The most active was Triclisia patens with an IC50 value of 1.5 mug/ml against Leishmania donovani. Annona purpurea and Alstonia macrophylla had IC50 values below 10 mug/ml against Trypanosoma brucei brucei. Annona purpurea was the most cytotoxic against KB cells. (C) 2003 Published by Elsevier Ireland Ltd.