Journal
NEUROBIOLOGY OF AGING
Volume 24, Issue 8, Pages 1023-1027Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2003.09.001
Keywords
Alzheimer's disease; synapses; neurofibrillary tangles; synaptic vesicle trafficking; gene expression profiling
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Funding
- NIA NIH HHS [AG14441] Funding Source: Medline
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Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer's disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking. (C) 2003 Elsevier Inc. All rights reserved.
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