Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 285, Issue 6, Pages E1151-E1160Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00324.2003
Keywords
caveolin-1; insulin receptor; glucose transporter 4
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Funding
- NIDDK NIH HHS [DK-61228, R01-DK-55758] Funding Source: Medline
- NIGMS NIH HHS [T32-GM-07288] Funding Source: Medline
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Caveolae are specialized membrane microdomains present within the plasma membrane of the vast majority of cell types. They have a unique composition in that they are highly enriched in cholesterol, sphingolipids, and their coat proteins the caveolins (-1, -2, and -3). In recent years it has been recognized that caveolae act as signaling platforms, serving as a concentrating point for numerous signaling molecules, as well as regulating flux through many distinct signaling cascades. Although caveolae are found in a variety of cell types, they are most abundant in adipose tissue. This fact has led to the intense study of the function of these organelles in adipocytes. It has now become apparent that effective insulin signaling in the adipocyte may be strictly dependent on localization of at least two insulin-responsive elements to caveolae (insulin receptor and GLUT4), as well as on a direct functional interaction between caveolin-1 and the insulin receptor. We present a critical discussion of these recent findings.
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