Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 112, Issue 11, Pages 1626-1632Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200320430
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Members of the bacterial genus Streptococcus are responsible for causing a wide variety of infections in humans. Many Streptococci use quorum-sensing systems to regulate several physiological properties, including the ability to incorporate foreign DNA, tolerate acid, form biofilms, and become virulent. These quorum-sensing systems are primarily made of small soluble signal peptides that are detected by neighboring cells via a histidine kinase/response regulator pair.
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