Journal
JOURNAL OF NEUROCHEMISTRY
Volume 87, Issue 6, Pages 1402-1412Publisher
WILEY
DOI: 10.1046/j.1471-4159.2003.02115.x
Keywords
alternative splicing; dorsolateral prefrontal cortex; real-time PCR; RNA editing; schizophrenia; serotonin 2C receptor
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Serotonin 2C receptor (5-HT2CR) heterogeneity in the brain occurs mostly from two different sources: (i) 5-HT2CR mRNA undergoes adenosine-to-inosine editing events at five positions, which leads to amino acid substitutions that produce receptor variants with different pharmacological properties; (ii) 5-HT2CR mRNA is alternatively spliced, resulting in a truncated mRNA isoform (5-HT2CR-tr) which encodes a non-functional serotonin receptor. 5-HT2CR mRNA editing efficiencies and the expression of the full-length and the truncated 5-HT2CR mRNA splice isoforms were analyzed in the prefrontal cortex of elderly subjects with schizophrenia vs. matched controls (ns = 15). No significant differences were found, indicating that there are no alterations in editing or alternative splicing of 5-HT(2C)Rs that are associated with schizophrenia in persons treated with antipsychotic medications. Quantitation of 5-HT2CR and 5-HT2CR-tr mRNA variants revealed that the expression of 5-HT2CR-tr was similar to 50% of that observed for the full-length isoform.
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