Journal
JOURNAL OF NEUROTRAUMA
Volume 20, Issue 12, Pages 1271-1292Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/089771503322686085
Keywords
GAP-43; growth associated protein; MAP1B; PSA-NCAM; regeneration; traumatic brain injury
Funding
- NIGMS NIH HHS [R01-GM34690] Funding Source: Medline
- NINDS NIH HHS [P50-NS08803] Funding Source: Medline
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The adult central nervous system (CNS) appears to initiate a transient increase in plasticity following injury, including increases in growth-related proteins and generation of new cells. Recent evidence is reviewed that the injured adult CNS exhibits events and patterns of gene expression that are also observed during development and during regeneration following damage to the mature peripheral nervous system (PNS). The growth of neurons during development or regeneration is correlated, in part, with a coordinated expression of growth-related proteins, such as growthassociated-protein-43 (GAP-43), microtubule-associated-protein-1B (MAP1B), and polysialylatedneural-cell-adhesion-molecule (PSA-NCAM). For each of these proteins, evidence is discussed regarding its specific role in neuronal development, signals that modify its expression, and reappearance following injury. The rate of adult hippocampal neurogenesis is also affected by numerous endogenous and exogenous factors including injury. The continuing study of developmental neurobiology will likely provide further gene and protein targets for increasing plasticity and regeneration in the mature adult CNS.
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