The centennial of the Cajal body

Exactly 100 years ago, the Spanish neurobiologist Santiago Ramon y Cajal described a new organelle in the nuclei of vertebrate neurons. Now called the Cajal body, this organelle occurs in many cell types in a wide variety of animals and plants. Recent studies indicate that the Cajal body has numerous roles in the assembly and/or modification of the nuclear-transcription and RNA-processing machinery.