Journal
FITOTERAPIA
Volume 74, Issue 7-8, Pages 720-724Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2003.07.004
Keywords
Morus alba; Artocarpus communis; Glycyrrhiza uralensis; Glycyrrhiza inflata; prenylflavonoids; antinephritis; superoxide anion radical
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Antinephritis activity of 5 prenylflavonoids similar to glabridin (1-5), isolated from Morus alba, Artocarpus communis, Glycyrrhiza uralensis and G. inflata, was evaluated in mice with glomerular disease (Masugi-nephritis). Oral administrations of artonin E (2) or licochalcone A (4) for 10 days (30 mg kg(-1) day(-1)) reduced the amount of urinary protein excretion compared to nephritic mice. ESR spectroscopy demonstrated that morusin (1) and licorisoflavan A (5) increased the radical intensity of sodium ascorbate by about two times. Morusin, licoricidin (3), licochalcone A and licorisoflavan A showed weak scavenging activity against superoxide anion radical. (C) 2003 Elsevier Science B.V. All rights reserved.
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