Journal
AMINO ACIDS
Volume 25, Issue 3-4, Pages 227-232Publisher
SPRINGER-VERLAG
DOI: 10.1007/s00726-003-0013-0
Keywords
dityrosine; oxygen free radicals; proteolysis; oxidative stress; protein damage
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Dityrosine is found in several proteins as a product of UV irradiation, gamma-irradiation, aging, exposure to oxygen free radicals, nitrogen dioxide, peroxynitrite, and lipid hydroperoxides. Interest of dityrosine in proteins is based on its potential as a specific marker for oxidatively damaged proteins and their selective proteolysis, hence it could be used as a marker for oxidative stress. Dityrosine is also the product of normal post-translational processes affecting specific structural proteins. Since post-translational modification of a given amino acid in a protein is equivalent to the substitution of that residue by an analogue, it has been proposed that the covalent modification of amino acids may serve as a marking step for protein degradation.
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