Journal
MAGNETIC RESONANCE IMAGING
Volume 21, Issue 10, Pages 1283-1293Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2003.08.028
Keywords
BOLD contrast; magnetic resonance spectroscopy; magnetic resonance imaging; balloon model; optical methods
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In this article, a review is made of the current knowledge concerning the physiology and metabolism of neuronal activity, as provided by the application of NMR approaches in vivo. The evidence furnished by other functional spectroscopic and imaging techniques, such as PET and optical methods, are also discussed. In spite of considerable amounts of studies presented in the literature, several controversies concerning the mechanisms underlying brain function still remain, mainly due to the difficult assessment of the single vascular and metabolic dynamics which generally influence the functional signals. In this framework, methodological and technical improvements are required to provide new and reliable experimental elements, which can support or eventually modify the current models of activation. (C) 2003 Elsevier Inc. All rights reserved.
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