Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 15, Issue 6, Pages 683-689Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2003.09.014
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Funding
- NCI NIH HHS [R01 CA52511] Funding Source: Medline
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Natural killer T (NKT) cells are a unique lymphocyte subtype implicated in the regulation of autoimmunity, particularly diabetes and experimental allergic encephalomyelitis in animal models. In some reports, NKT-cell regulation was revealed only following vigorous activation by a synthetic glycolipid, a process that might not occur naturally. Patients with diverse autoimmune diseases have reduced NKT-cell counts and, in diabetes and multiple sclerosis, effective NKT-cell regulation correlates with the secretion of Th2 cytokines. Although current controversy surrounds the importance of NKT cells and their modes of action, they represent a potentially important clinical target.
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