Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 47, Issue 12, Pages 3982-3984Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.12.3982-3984.2003
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Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts, has shown in vitro activity against Helicobacter pylori. We evaluated the effect of sulforaphane in vivo against this bacterium by using human gastric xenografts in nude mice. H. pylori was completely eradicated in 8 of the 11 sulforaphane-treated grafts. This result suggests that sulforaphane might be beneficial in the treatment of H. pylori-infected individuals.
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