Journal
PATHOLOGIE BIOLOGIE
Volume 51, Issue 10, Pages 569-573Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.patbio.2003.09.003
Keywords
aging; skin; matrix metalloproteinase; tissue inhibitor of metalloproteinase
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Up regulation of matrix metalloproteinases (MMPs), particularly collagenase-1 (MMP-1), stromelysin-1 (MMP-3) and gelatinase A (MMP-2) is responsible for the lysis of dermal collagen and elastin fibers during chronological skin aging. Tissue inhibitor of metalloproteinase-1 (TIMP-1) is one representative of the natural MMP inhibitor family, encompassing four members. Its expression is decreased with fibroblast senescence, both ex vivo and in. vivo, thus contributing to increased catabolic activity within dermis. TIMP-1 displays multiple biological functions: It inhibits most MMPs, except membrane-type MMP subfamily, with K-i in the subnanomolar range, but also interacts with the hemopexin-like (PEX) domain of pro MMP-9. Besides, it exhibits keratinocyte and fibroblast growth factor-like activity and has been described as a cell survival factor. (C) 2003 Editions scientifiqqes et medicales Elsevier SAS. All rights reserved.
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