Frictional properties of poly(MPC-co-BMA) phospholipid polymer for catheter applications

A fundamental understanding of surface properties of the biomaterials at a nanometer scale should be generated in order to understand cellular responses of the tissue to biomaterials thereby minimizing or eliminating tissue trauma at a macrometer scale. In this study poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) ([poly(MPC-co-BMA]) was evaluated as a potential coating material for vascular applications to provide smooth catheterization using atomic force microscopy (AFM) techniques. A uniform coating of [poly(MPC-co-BMA] equivalent to a thickness of 2.5 mum on a polyurethane (PU) catheter material was provided using dip casting technique. Using a contact mode AFM, no significant difference in surface roughness (R-a) and frictional force (f) between uncoated (R-a = 10.2 +/- 1.9 nm, f = 0.907 +/- 0.02) and coated (R-a 11.7 +/- 1.8 nm, f = 0.930 +/- 0.06) surfaces was observed under dry conditions. However, under wet conditions the R-a of the coated surface (3.4 +/- 1.0 nm) was significantly lower than uncoated PU surface (9.0 +/- 1.8 nm), The coating on PU substrate offered the least frictional resistance (f = 0.004 +/- 0.001) illustrating enhanced boundary lubrication capability due to hydration of phosphoryleholine polymer as compared to a significantly higher f for uncoated PU (0.017 +/- 0.007) surfaces. These tribological and chemical characteristics of the [poly(MPC-co-BMA)] coating could increase the overall efficacy of PU for clinical applications. (C) 2003 Elsevier Ltd. All rights reserved.