Journal
NATURE REVIEWS IMMUNOLOGY
Volume 3, Issue 12, Pages 973-983Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1245
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Much excitement of the past five years in the area of T-cell-antigen recognition has centred around the immunological synapse - a complex cellular structure that forms at the interface of a T cell and a cell that expresses the appropriate peptide-MHC complexes. Thanks to new imaging technologies, we are now beginning to understand the role of cell-surface molecules and some of their attendant signalling modules in the context of cell-to-cell communication. Progress has been so rapid that T-cell-antigen recognition might be the first system in which the molecular basis of cell - cell recognition is understood.
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