Journal
MOVEMENT DISORDERS
Volume 18, Issue 12, Pages 1517-1520Publisher
WILEY-LISS
DOI: 10.1002/mds.10607
Keywords
Parkinson's disease; subthalamic stimulation; axial symptoms; neuropathology
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We report on a patient with Parkinson's disease (PD) who was moderately improved by stimulation of the subthalamic nucleus (STN) and died 2 years after electrode implantation. After neurosurgery, symptoms that had responded to levodopa treatment preoperatively continued to improve. Postural instability, dysarthria, and cognitive impairment continued to worsen, despite STN stimulation and levodopa treatment. Postmortem examination of the brain confirmed the diagnosis of PD and showed that the electrodes had been correctly positioned within the STN. The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment. (C) 2003 Movement Disorder Society.
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