Journal
AMERICAN JOURNAL OF CARDIOLOGY
Volume 92, Issue 11, Pages 1362-1365Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2003.08.033
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- NHLBI NIH HHS [R01-HL69146] Funding Source: Medline
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Hyperglycemia has been linked to adverse outcomes after myocardial infarction. We characterized the effect of selected concentrations of glucose or mannitol on platelet function in whole blood samples from healthy volunteers and from patients with and without diabetes mellitus. Activation of platelet glycoprotein IIb/IIIa and P-selectin expression was increased similarly after addition of isosmotic concentrations of glucose and mannitol, suggesting that increased osmolarity associated with hyperglycemia increases platelet reactivity. (C) 2003 by Excerpta Medica, Inc.
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