Journal
JOURNAL OF VIROLOGY
Volume 77, Issue 24, Pages 13412-13417Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.24.13412-13417.2003
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Funding
- NCI NIH HHS [P30 CA006927, CA71515, CA06927, R01 CA071515] Funding Source: Medline
- NIAID NIH HHS [AI40385, R01 AI040385] Funding Source: Medline
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An essential step in human immunodeficiency virus type 1 (HIV-1) replication is the movement of the viral preintegration complex from the cytoplasm into the nucleus. The pathway(s) and timing for HIV-1 DNA nuclear entry in cycling cells have not been established. Here, we show that if cycling cells are infected before S phase, viral DNA can be integrated prior to passage of the host DNA replication fork through the integration site, as indicated by stable inheritance in both daughter cells. We conclude that efficient nuclear entry can occur independently of mitotic nuclear disassembly in cycling cells.
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