Journal
MICROBIAL DRUG RESISTANCE
Volume 9, Issue 4, Pages 329-336Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/107662903322762752
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Funding
- NIAID NIH HHS [AI46610] Funding Source: Medline
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Penicillin-binding proteins (PBPs) mediate susceptibility to beta-lactam antibiotics. PBP 4, although not essential for survival, has been associated with low-level resistance to beta-lactam antibiotics. To determine its contribution to survival of Staphylococcus aureus cells exposed to beta-lactams, the PBP 4 gene (pbp4) was disrupted and then complemented in the methicillin-susceptible strain RN4220 and the homogeneous methicillin-resistant strain COL. Depending on the antibiotic tested, the presence or absence of an intact pbp4 has no effect or only a modest effect on growth measured by population analysis. These data indicate that PBP 4 is a relatively unimportant target of beta-lactams not only in methicillin-susceptible but also methicillin-resistant S. aureus.
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