Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 15, Issue 6, Pages 717-724Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2003.10.002
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Funding
- NIGMS NIH HHS [R01 GM068016-01A1, 1R01 GM068016-01A1] Funding Source: Medline
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Inhibitor of apoptosis proteins (IAPs) are a conserved class of proteins that control apoptosis in both vertebrates and invertebrates. They exert their anti-apoptotic function through inhibition of caspases, the principal executioners of apoptotic cell death. Recent advances in vertebrates and Drosophila have demonstrated that IAPs use ubiquitin conjugation to control the stability, and thus the activity, of select target proteins. The Drosophila IAP1 gene is an instructive example: it employs at least two distinct ubiquitin-dependent mechanisms of protein destruction. The apoptosis-inducing genes grim, reaper and hid modulate these mechanisms, and determine the outcome.
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