Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 33, Issue 5, Pages 903-910Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0731-7085(03)00379-0
Keywords
trimipramine; multicommutated flow system; reversed flow; binary sampling; spectrophotometry
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In this work an automated multicommutated flow methodology was implemented for the spectrophotometric determination of trimipramine in pharmaceutical preparations by oxidation with ammonium monovanadate in acidic medium. The developed procedure exploits a new approach for sample/reagent intermixing by combining binary sampling with flow-reversal. Rather than inserting the sample as a single continuous volume the intercalation of multiple small sample and reagent aliquots, under a time-based control, created multiple reaction interfaces that promoted reaction zone homogenisation even in limited dispersion conditions. Additionally, the reaction interfaces were reversed, increasing mutual zone penetration, which contributed to a faster reaction development while assuring a low dispersion pattern. A linear range of determination was verified for trimipramine concentrations between 1.0 and 18.0 mug ml(-1) with a relative standard deviation (n = 10) lower than 1.69% and a sample throughput of about 26 samples per hour. The results were in agreement with those obtained by the reference procedure with relative deviations lower then 2.37%. (C) 2003 Elsevier B.V. All rights reserved.
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