Journal
FEBS LETTERS
Volume 555, Issue 2, Pages 311-316Publisher
WILEY
DOI: 10.1016/S0014-5793(03)01265-1
Keywords
glucosylation; curcumin; water solubility; cell suspension culture; Catharanthus roseus
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Catharanthus roseus cell suspension cultures converted exogenously supplied curcumin to a series of glucosides, none of which has been found in nature so far. The efficiency of glucosylation was dependent on culture stage of the cells and medium sucrose concentration. Methyl jasmonate and salicylic acid enhanced the glucoside formation only when they were added to the cultures prior to the addition of curcumin. The glucoside yield was 2.5 mumol/g fresh weight of the cells at an optimal culture condition. The water solubility of curcumin-4'4-O-beta-D-digentiobioside was 0.65 mmol/ml, which was 20 million-fold higher than that of curcumin. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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