Journal
BRAIN RESEARCH
Volume 992, Issue 2, Pages 288-293Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2003.08.042
Keywords
neuropathic pain; inflammatory pain; protein kinase A; protein kinase C; spinal cord
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In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation exhibited a spinal protein kinase C (PKC)-dependent neuropathic pain-like state. In contrast, an intraplanter injection of inflammatory agent caused a protein kinase A (PKA)-related thermal hyperalgesia. These findings suggest that the substantial activation of spinal PKC and PKA may differentially contribute to the development of respective chronic pain-like state in mice. (C) 2003 Elsevier B.V. All rights reserved.
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