Journal
SCIENCE
Volume 302, Issue 5651, Pages 1760-1765Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1088417
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Funding
- NIMH NIH HHS [MH20016-05] Funding Source: Medline
- NINDS NIH HHS [F30 NS04696701] Funding Source: Medline
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Cranial radiation therapy causes a progressive decline in cognitive function that is linked to impaired neurogenesis. Chronic inflammation accompanies radiation injury, suggesting that inflammatory processes may contribute to neural stem cell dysfunction. Here, we show that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neurogenesis after endotoxin-induced inflammation and augments neurogenesis after cranial irradiation.
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