Journal
JOURNAL OF CONTROLLED RELEASE
Volume 93, Issue 2, Pages 183-191Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2003.07.002
Keywords
ODN; PEG; micelles; conjugate; delivery
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The conjugate of antisense c-raf oligonucleotide (ODN) and poly(ethylene glycol) (PEG) was synthesized for intracellular ODN delivery. When combined with polyethylenimine (PEI), the ODN-PEG conjugate self-associated to form polyelectrolyte complex micelles in aqueous solution. The effective hydrodynamic diameter of the micelles was ca. 70 nm with a narrow size distribution. Flow cytometry analysis indicated that the cellular uptake of the micelles by A2780 cells was much higher than that of ODN alone. The micelles also showed a superior antiproliferative activity against ovarian cancer cells in vitro and in vivo. (C) 2003 Elsevier B.V. All rights reserved.
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