Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 84, Issue 5, Pages 611-616Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/bit.10815
Keywords
protein interactions; solvation forces; molecular variation; lysozyme; second virial
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We investigated the influence of solvation forces on protein-protein interactions for two forms of lysozyme: hen egg white (HEWL) and turkey egg white (TEWL). Turkey egg white has more surface exposed hydrophobic residues than HEWL and the protein-protein interactions of TEWL are shown to be more attractive than those of HEWL, for the conditions studied. The importance of including a solvation term in the potential of mean force model, to account for molecular variation in protein surface characteristics, is highlighted. We also show that the magnitude of this solvation term can be estimated using readily available data. (C) 2003 Wiley Periodicals, Inc.
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